Biotin and derivatives
Medchemexpress LLC DBCO-Biotin | 1418217-95-4 | MFCD22380751 | 98.5% | 502.63 g/mol | C28H30N4O3S | 100MG
DBCO-Biotin is a dibenzocyclooctyne-linked biotin reagent designed for copper-free click chemistry and efficient biotinylation of azide-functionalized molecules. It is used for catalyst-free conjugation in labeling, enrichment, and linker assembly workflows, including PROTAC synthesis. The reagent is DMSO-soluble and supplied with recommended storage conditions to preserve stability.
Medchemexpress LLC Bis-PEG21-NHS ester | 2221948-98-5 | 99.9% | 500 MG
Bis-PEG21-NHS ester is a PEG/Alkyl/ether-based PROTAC linker primarily used in the synthesis of PROTACs. It also serves as a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs).
- PEG/Alkyl/ether-based linker
- PROTAC linker for targeted protein degradation
- Cleavable ADC linker
- Utilizes the ubiquitin-proteasome system
- Suitable for PROTACs synthesis
- Suitable for ADC synthesis
![Medchemexpress LLC N-[6-(biotinamido)hexyl]-3-(2-pyridyldithio)propionamide | 129179-83-5 | MFCD00078541 | 99.7% | C24H37N5O3S3 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000259744.png-250.jpg)
Medchemexpress LLC N-[6-(biotinamido)hexyl]-3-(2-pyridyldithio)propionamide | 129179-83-5 | MFCD00078541 | 99.7% | C24H37N5O3S3 | 10MG
Biotin-HPDP is a thiol-reactive biotinylation reagent that labels free protein thiols through a cleavable disulfide linkage, enabling reversible biotinylation for affinity purification and recovery of native proteins. It is supplied as a white to off-white solid with high reported purity and defined storage recommendations.
- Thiol-reactive biotinylation reagent for cysteine labeling.
- Cleavable disulfide linkage enables reversible labeling.
- Suitable for affinity purification and protein recovery.
- High reported purity (99.7%).
- Stable as powder at -20°C for long-term storage.
- Available in small pack sizes for biochemical assays.
Apexbio Technology LLC Biotin-16-dCTP 200ul (5 mM)
Biotin-16-dCTP is a biotinylated derivative of deoxycytidine triphosphate (dCTP) designed for enzymatic incorporation into nucleic acids during polymerase-mediated processes Structurally it consists of a dCTP core conjugated via a 16-atom spacer arm to a biotin moiety facilitating effective interaction with streptavidin This specific biotin-streptavidin binding affinity enables applications in nucleic acid labeling detection and affinity purification protocols PCR experiments indicate that biotin-16-dCTP incorporation by Taq polymerase can reach approximately 90% substitution without considerable reduction in amplification yield demonstrating greater polymerase compatibility compared to biotin-16-dUTP analogues
Medchemexpress LLC Biotin-DADOO (Biotinyl-3,6-dioxaoctanediamine) | 138529-46-1 | 98.0% | 1 G
Biotin-DADOO is an amine compound that contains biotin and functions as a biotinylation reagent. It acts as an amino component, involved in the nucleophilic ring-opening reaction of epoxidized ω-double bonds during the synthesis of biotinylated inhibitor derivatives. This reagent can be conjugated with carboxymethyl cellulose derivatives and is utilized in the synthesis of biotin-estradiol conjugates for enzyme immunoassays. It also finds application in influenza A research.
- Functions as a biotinylation reagent.
- Participates in nucleophilic ring-opening reactions during biotinylated inhibitor synthesis.
- Can be conjugated with carboxymethyl cellulose derivatives.
- Involved in the synthesis of biotin-estradiol conjugates for enzyme immunoassays.
- Used in influenza A research.
Medchemexpress LLC LAIR1 Human Biotin 20ug
LAIR1 protein has a negative regulatory effect on NK cells B cells and T cells It activates the phosphatases PTPN6 and PTPN11 inhibits calcium increases in B cells and regulates cytokine production in CD4 T cells LAIR1 Protein Human (Biotinylated HEK293 Avi-His) is the recombinant human-derived LAIR1 protein expressed by HEK293 with C-Avi C-6 His labeled tag
Medchemexpress LLC Biotin (Standard) | 58-85-5 | 99.8% | 50 MG
Biotin (Standard) is the analytical standard of Biotin, also known as vitamin B7. It serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids.
- Analytical standard grade
- Reference standard for assay
- Used in qualitative research experiments
- Used in quantitative research experiments
- Used in methodological research experiments
- Suitable for HPLC applications
- Suitable for GC applications
- Suitable for MS applications
- Essential for cell growth
- Essential for fatty acid production
- Essential for metabolism of fats and amino acids
Medchemexpress LLC Biotin | 58-85-5 | 99.1% | 1 ML
Biotin, also known as vitamin B7, acts as a coenzyme for five carboxylases in humans. It is involved in the synthesis of fatty acids, isoleucine, and valine, as well as in gluconeogenesis. Biotin is essential for cell growth, the production of fatty acids, and the metabolism of fats and amino acids.
- Acts as a coenzyme for five human carboxylases
- Involved in the synthesis of fatty acids, isoleucine, and valine
- Involved in gluconeogenesis
- Essential for cell growth
- Essential for the production of fatty acids
- Essential for the metabolism of fats and amino acids
Medchemexpress LLC Biotin-EDA | 111790-37-5 | 97.5% | 50 MG
Biotin-EDA is an alkyl chain-based PROTAC linker used in the synthesis of PROTACs. This product is for research use only and is not sold to patients.
- Alkyl chain-based PROTAC linker
- Used in the synthesis of PROTACs
- For research use only
- Solid, white to off-white appearance
- Soluble in DMSO (requires ultrasonic)
- Store solid at 4°C, protected from light
- Store in solvent at -80°C for 6 months or -20°C for 1 month, protected from light
Medchemexpress LLC Biotin-EDA | 111790-37-5 | 97.5% | 1 G
Biotin-EDA is an alkyl chain-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are designed to exploit the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. This compound has a molecular weight of 286.39 and appears as a solid, white to off-white substance.
- Alkyl chain-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs contain two different ligands connected by a linker
- PROTACs exploit the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Solid, white to off-white appearance
- For research use only
Medchemexpress LLC PC azido-PEG3-NHS carbonate ester | 1802907-96-5 | MFCD29052189 | 98.7% | 640.60 g·mol⁻¹ | C26H36N6O13 | 5 MG
PC Azido-PEG3-NHS carbonate ester is a photocleavable, heterobifunctional linker designed for covalent labeling of primary amines and for introducing an azide handle for click chemistry. The reagent couples to amine groups via an NHS carbonate, and the photocleavable moiety enables light-triggered release of the attached cargo; supplied as a dry research reagent with recommended cold storage.
Medchemexpress LLC 2H-1,2-oxazine derivative (TFA salt) | 96.0% | 1165.34 g/mol | C57H87F3N8O14 | 25 MG
NHS-modified monomethyl auristatin F (TFA) is an NHS-activated MMAF derivative supplied as a trifluoroacetate salt and used as an intermediate in antibody-drug conjugate (ADC) linker synthesis. It is provided for research applications and is intended for building drug-linker conjugates.
- NHS-activated derivative suitable for conjugation to amines.
- Intended as an intermediate for antibody-drug conjugate synthesis.
- Purity around 96.0% by HPLC.
- Molecular weight approximately 1165.34 g/mol.
- Provided as a TFA salt with formula C57H87F3N8O14.
Medchemexpress LLC Mal-PEG1-NHS ester | 1807518-72-4 | 310.26 g/mol | C13H14N2O7 | 1 G
Mal-PEG1-NHS ester is a PEG-based bifunctional linker containing a maleimide group and an N-hydroxysuccinimide (NHS) ester. It is used for bioconjugation in the synthesis of antibody-drug conjugates (ADCs) and proteolysis-targeting chimeras (PROTACs), enabling selective thiol-to-amine coupling via maleimide and NHS chemistries.
- Bifunctional maleimide and NHS ester chemistry for thiol and amine coupling.
- PEG spacer increases solubility and reduces steric hindrance.
- Non-cleavable linker suitable for ADC and PROTAC synthesis.
- Available in multiple pack sizes, including 1 g for preparative use.
- Molecular weight 310.26 g/mol and formula C13H14N2O7.
Medchemexpress LLC Biotin-EDA | 111790-37-5 | 97.5% | 5 G
Biotin-EDA is an alkyl chain-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs themselves consist of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein, leveraging the intracellular ubiquitin-proteasome system to degrade target proteins selectively.
- Utilized in the synthesis of PROTACs
- PROTACs consist of two different ligands connected by a linker
- One ligand targets an E3 ubiquitin ligase
- The other ligand targets a specific protein
- Leverages the intracellular ubiquitin-proteoteasome system to degrade target proteins selectively
- Alkyl-chain based
Medchemexpress LLC Bis-PEG21-NHS ester | 2221948-98-5 | 98.0% | 1237.34 | C54H96N2O29 | 10 MG
Bis-PEG21-NHS ester is a bifunctional polyethylene glycol (PEG) linker bearing two N-hydroxysuccinimide (NHS) ester reactive groups separated by a PEG21 spacer. It is supplied as a high-purity reagent for bioconjugation, PROTAC synthesis, and antibody-drug conjugate construction.
- Two NHS ester reactive groups for amine coupling.
- PEG21 spacer provides hydrophilicity and flexibility.
- High purity suitable for conjugation chemistry applications.
- Intended for PROTAC and ADC linker development and general PEGylation chemistry.
- Available in small-scale quantities for research use.